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We all know about pituitary shutdown (the hypothalamic stops pulsing the pituitary signals to secrete LH and FSH) this of course leads to testicular atrophy and no natty test production and low sperm count. However more functionality in our brains is suppressed via this glandular dormancy. Our pituitary and hypothalamic glands control more than sex hormone assembly (if you will) they also regulate certain neurotransmitter functions-one of which controls stress levels and adaptation to stressful stimulus. When the glands are not functioning as intended due to anabolic shutdown stress levels spike (hence cortisol elevation) leading to anxiety and ultimately Chronic Depression in many cases!