Reduced CoQ (CoQH 2 ) diffuses in the lipid phase of the membrane and donates its electrons to complex III, whose principal components are the heme proteins known as cytochromes b (encoded by the MT-CYB gene) and c1 (encoded by the CYC1 gene) and a non-heme-iron protein, known as the Rieske iron sulfur protein (encoded by the UQCRFS1 gene). Complex III is known as ubiquinol-cytochrome c oxidoreductase or as CoQ-cytochrome reductase and often as the cytochrome bc 1 complex. Complex III is composed of 11 protein subunits, all of which, excepting cytochrome b , are encoded by the nuclear genome. The MT-CYB, CYC1, and UQCRFS1 encoded proteins constitute the electron transfer center of complex III. In contrast to the heme of hemoglobin and myoglobin, the heme iron of all cytochromes participate in the cyclic redox reactions of electron transport, alternating between the oxidized (Fe 3+ ) and reduced (Fe 2+ ) forms. The electron carrier from complex III to complex IV is the smallest of the cytochromes, cytochrome c (molecular weight 12,000; encoded by the CYCS gene). The releaase of cytochrome c from the mitochoindria to the cytosol is the major trigger of the mitochondrially-induced apoptosis pathway .
The hypothalamus may be the culprit when it comes to excessive levels of cortisol in the blood. It is responsible for starting the process that leads to the secretion of cortisol by the adrenal glands. The hypothalamus first manufactures corticotrophic-releasing hormone (CRH). The pituitary gland is then stimulated into releasing adrenocorticotrophic hormone (ACTH). This hormone then makes the adrenal glands secret cortisol in the blood. When the endocrine system is functioning properly, the hypothalamus monitors the level of cortisol that is in the blood. When the level rises, the hypothalamus slows down its influence on the pituitary gland in production of CRH. When cortisol levels become reduced, the hypothalamus causes the pituitary gland to produce more CRH. In a person who is depressed, the hypothalamus may continuously influence the pituitary to produce CRH without regard to the amount of cortisol that is in the blood.
To keep you healthy, you have to follow your biological clock to do your work and rest! Rest is for your internal doctor to do its job to repair and recover your body to the good normal conditions, and ready for next day! If you mess up your body’s biological clock, you will have some kind of diseases occur soon and later. Keep in mind, rest is prepared for a longer life to go. So, work hard, but rest on time as well, no matter what! Your body health is the most important job for you to do in your whole life, not your projects, not your wealth, not your reputation, because if your body is gone, your everything is gone as well.