Biosynthesis of adrenocortical steroid hormones

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Polyketides are structurally a very diverse family of natural products with diverse biological activities and pharmacological properties. [3] They are broadly divided into three classes: type I polyketides (often macrolides produced by multimodular megasynthases ), type II polyketides (often aromatic molecules produced by the iterative action of dissociated enzymes ), and type III polyketides (often small aromatic molecules produced by fungal species). Polyketide antibiotics , antifungals , cytostatics , anticholesteremic , antiparasitics , coccidiostats , animal growth promoters and natural insecticides are in commercial use. [ citation needed ]

The MEP pathway starts with the condensation of pyruvate and D-glyceraldehyde-3-phosphate to 1-deoxy-D-xylulose-5-phosphate (DXP or DOXP). The key isomers DMAPP and IPP are subsequently formed via a series of enzymatic steps starting with the conversion of DXP to 2C-methyl-D-erythritol-4-phosphate (MEP). Enzymes of this MEP pathway are attractive targets for the development of drugs targeting infectious diseases such as malaria and tuberculosis, because this pathway occurs in pathogenic prokaryotes but is absent in human metabolic pathways.

Biosynthesis of adrenocortical steroid hormones

biosynthesis of adrenocortical steroid hormones

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