Letrozole is a nonsteroidal competitive inhibitor of the aromatase enzyme system; it inhibits the conversion of androgens to estrogens. In adult nontumor- and tumor-bearing female animals, letrozole is as effective as ovariectomy in reducing uterine weight, elevating serum LH, and causing the regression of estrogen-dependent tumors. In contrast to ovariectomy, treatment with letrozole does not lead to an increase in serum FSH. Letrozole selectively inhibits gonadal steroidogenesis but has no significant effect on adrenal mineralocorticoid or glucocorticoid synthesis.
I really want to be able to do an Aromatase Inhibitor to lower my chances of recurrence, but I have to be able to move. My daughter was here this weekend and she was upset by how badly I look and the condition I am in. She is an only child and it weighs heavily on her that she is not here and able to care for me. She is an angel when she is here . She said enough is enough with this treatment. I told her I would stick with it as long as I could take care of myself. I go tomorrow for an infusion and willmsee about what my next move is. This is dreadful.
Thank you for your input Terri. I have looked at the drugs online and they do seem comparable so maybe I will switch and see what happens until my next oncology appt in May. One of my concerns is that I'd never heard of Aromasin before - only the main 3 Tamoxifen, Femara and Arimidex- so am a little hesitant to switch but I must say I am seeing relief in my joint pain. I DO however have arthritis in all my joints which causes pain I have to live with, but I think now that the Femara was increasing the pain plus causing more muscle pain as well. Only time will tell. My thanks again for your help.