Many Tailfeathers members (myself included) have succeeded in medicating birds orally when we thought we couldn't. In fact, in the photos of Bruce and Pez below, this was a first for both birds. Neither had ever been medicated before. I gave them water from a syringe for the sole purpose of getting photos for this article. The entire process took only about 5 minutes, with minimal stress. I am a veteran medicater of budgies, but I did not expect it to be this easy with Bruce and Pez. Every bird will eventually get sick in its lifetime, and when this happens, medicating it is inevitable. Face it - you're going to have to learn how to do this sometime!
In an open-label study, six pediatric patients (age range, weeks to months) with GER received metoclopramide mg/kg oral solution every 6 hours for 10 doses. The mean peak plasma concentration of metoclopramide after the tenth dose was 2-fold ( µg/L) higher compared to that observed after the first dose (29 µg/L) indicating drug accumulation with repeated dosing. After the tenth dose, the mean time to reach peak concentrations ( hr), half-life ( hr), clearance ( L/h/kg), and volume of distribution ( L/kg) of metoclopramide were similar to those observed after the first dose. In the youngest patient (age, weeks), metoclopramide half-life after the first and the tenth dose ( and hr, respectively) was significantly longer compared to other infants due to reduced clearance. This may be attributed to immature hepatic and renal systems at birth.
Midazolam, when taken during the third trimester of pregnancy, may cause risk to the neonate, including benzodiazepine withdrawal syndrome, with possible symptoms including hypotonia , apnoeic spells, cyanosis , and impaired metabolic responses to cold stress. Symptoms of hypotonia and the neonatal benzodiazepine withdrawal syndrome have been reported to persist from hours to months after birth.  Other neonatal withdrawal symptoms include hyperexcitability, tremor, and gastrointestinal upset (diarrhea or vomiting). Breastfeeding by mothers using midazolam is not recommended.