"It's an approach that makes sense and that we're all endeavoring to get to, and sometimes we can do that, but we're still defining what those characteristics are," Dr Williams said. The neuropathic pain categories that present the biggest challenges for genetics-based stratification are acquired ones, such as neuropathic pain resulting from diabetes, stroke, cancer, trauma, shingles, or anything else that's polygenic or specific to an acquired disease. But eventually overcoming these challenges to offer personalized approaches to pain management will pay off in multiple ways.
Generally, the pain level of NP is larger than the pain level of nociceptive pain and may cause chronic pain [ 24 ]. We noted significant differences in all pain scores, grip power, and tip pinch between the hands unlikely to have NP and those possible or likely to have NP before surgery (Table 4 ). Whether the main reason for the motor weakness was pain or thenar muscle disturbance is unclear. However, thenar muscle weakness does not directly affect the grip power or tip pinch (thumb-index). Therefore, the weakness of the grip power and tip pinch (thumb-index) was likely due to NP.