Midwest: I’m still fairly new here, but I’m loving your wisdom. (I’m a Midwest girl myself… ;-)…) And what you said is so true about allowing fish to swim by. I’m very up front about what I’m looking for in my profile as well as what I’m able to provide. I realize that we each have different needs and desires. So I always consider honesty the best policy. I assume there is always someone out there looking for what I have to offer… I just need to be still… Be patient… And wait.
In clinical practice, this means that it takes 4 to 5 times the half-life for a drug's serum concentration to reach steady state after regular dosing is started, stopped, or the dose changed. So, for example, digoxin has a half-life (or t ½ ) of 24–36 h; this means that a change in the dose will take the best part of a week to take full effect. For this reason, drugs with a long half-life (., amiodarone , elimination t ½ of about 58 days) are usually started with a loading dose to achieve their desired clinical effect more quickly.